SUN-088 EFFICACY AND SAFETY OF TOLVAPTAN FOR HYPONATREMIA IN ADVANCE CKD
نویسندگان
چکیده
منابع مشابه
Tolvaptan, hyponatremia, and heart failure
Tolvaptan is the first FDA-approved oral V(2) receptor antagonist for the treatment of euvolemic and hypervolemic hyponatremia, in patients with conditions associated with free water excess such as heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone secretion. Tolvaptan inhibits the binding of arginine vasopressin to the V(2) receptors on the collecting ducts of the...
متن کاملTolvaptan and its potential in the treatment of hyponatremia
Tolvaptan is a selective arginine vasopressin (AVP) V(2) receptor blocker used to induce free water diuresis in the treatment of euvolemic or hypervolemic hyponatremia. Currently the orally active medication is in the final stages prior to approval by the FDA for outpatient therapy. It appears to be safe and effective at promoting aquaresis and raising serum sodium levels in both short- and lon...
متن کاملOral tolvaptan is safe and effective in chronic hyponatremia.
Vasopressin antagonists increase the serum sodium concentration in patients who have euvolemia and hypervolemia with hyponatremia in the short term (</=30 days), but their safety and efficacy with longer term administration is unknown. SALTWATER was a multicenter, open-label extension of the Study of Ascending Levels of Tolvaptan in Hyponatremia (SALT-1 and SALT-2). In total, 111 patients with ...
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INTRODUCTION Hyponatremia is the most common electrolyte abnormality in patients who are admitted to the hospital. Affecting 5.5% of patients, hyponatremia is manifested as a decrease in serum sodium levels, accompanied by symptoms ranging from nausea to seizures and coma. The presence and degree of these symptoms are dependent on the rate of the decrease in sodium as well as the absolute sodiu...
متن کاملThe first case of levetiracetam-induced and tolvaptan-resistant hyponatremia.
Hyponatremia is frequently seen in heart failure patients and has a high mortality rate. If not treated adequately, acute and chronic hyponatremia may worsen the prognosis of heart failure. Despite its high incidence in heart failure patients, other underlying conditions that possibly lead to the incidence of hyponatremia may be underestimated, thus making its treatment more difficult. In this ...
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2020
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2020.02.614